•
1 1

6-25 Mice Model Creation Fundraising Campaign: ($150 - $700 Donations)

6-25 Mice Model Creation Fundraising Campaign: ($150 - $700 Donations)

$150.00 USD
$150.00 USD
Sale Sold out
Donation Amount
∆6-25 Mice Model Creation: Phase One's Initial Study: Exons 6 & 7 Skipping
To test the efficacy of double exon-skipping of exons 6 & 7 in order to correct out-of-frame mutations (severe Duchenne Muscular Dystrophy) and convert them to an in-frame (less severe, higher chance of ambulation and prevention of premature death)

See full Pipeline & Campaign Details Here.

Targeted Start Date
January, 3rd 2025
 
Estimated Timeline of ∆6-25 Mice Model Creation 
March, 31, 2025
 
∆6-25  Mice Model Initial Cost (Our Campaign's Goal)
$25k

∆6-25  Mice Model Long-Term Cost
(If Exon-Skipping of exons 6& 7 would lead to positive outcome - Please see chart below) TBD

Why Mice Model?
To test the end result before starting exons 6 & 7 skipping Study & Process: 
Instead of developing the ∆8-25 hDMD/mdx model and then testing all the therapies to see if they'll work, we should focus on the end result and work on the development of ∆6-25 hDMD/mdx model. When exons 6 and 7 are skipped, the resultant missing segment will be ∆6-25. If this mouse model shows mild Becker phenotype, then we'll know for certain that the exon-skipping of exons 6 & 7 therapy of Dr. Nicolas Wein of Nationwide Children's Hospital will become an effective treatment

Current Accessibility of Mice Model Creation for Interested/Active Parents & Patients
  • Current State: 
    • Only Research Facilities/Pharmaceuticals/Universities decide what mice models will be created based on their relevant studies in their pipelines. Parents have no say in that process. 
    • There are no organizations in the world right now offering to create mice models for interested/active parents or patients for their specific mutation.
  • Our Vision To Change That Reality:
    • We are aiming to enable parents, patients, physicians as well as pharmaceutical companies to test the new or already-in-market drugs/trial studies by raising capital for any new mutation that is submitted to our nonprofit, and fund the most credible research facilities to create mice models for each of the mutations.
View full details

  • Call us

    If you ecounter any problems in the payment processing, please call us at: (832)480-3546

  • Hope for Luka

    Hope for Luka Inc. is a 501c3 registered tax-exempt nonprofit organization. Federal Tax ID: #88-4259525